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Top 8 Best Weight Loss Supplements That Actually Deliver Results

Updated
May 19, 2025
Published
May 19, 2025
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Are you trying your best to shed those extra pounds, but the scale isn’t budging? Sometimes, an extra push is what we need to support our regular diet and exercise routine. In this article, you can discover our list of the top 8 weight loss supplements that can help you pick the missing element in your weight loss journey. Whether you’re looking for powders to boost your metabolism or pills to curb your cravings, we’ve got a range of weight loss supplements and dietary products that you can choose from!

8 Best Weight Loss Supplements

1. Liraglutide

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Also known under the brand name Saxenda, Liraglutide is actually an injectable medication that helps with weight loss. It does this by mimicking gut hormones that make your brain think that it’s full, which will reduce your appetite and calorie intake.

Some individuals are observed to lose 5-10% of their body weight. Still, this medication is not recommended for those who have any personal or family history of medullary thyroid carcinoma or Multiple Endocrine Neoplasia type 2. You can also give this one a pass if needles give you the jitters!

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2. Performix-SST X Thermogenic

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This cinnamon-flavored pill can help you achieve your weight loss goals by boosting your energy, focus, and metabolism. The standout element in this supplement is Capsimax®, which includes concentrated capsaicin, an active ingredient in chilli peppers.

A daily dose of two capsules helps with increasing your energy expenditure and claims to burn an extra 100 calories a day. As Performix-SST X Thermogenic is a combo of stimulants and thermogenic agents, it’s perfect for those who’d like to see enhanced performance alongside losing weight.

3. Qsymia

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This prescription capsule is approved for people 12 years and older and can help with decreasing appetite and cravings. It can result in an average weight loss of 5-10%, with 70% of adults losing a minimum of 5% of their body weight in a year [1].

However, look out for side effects like dizziness, dry mouth, and insomnia. Since Qsymia contains a controlled substance called phentermine, it’s not recommended for people with a history of substance abuse, along with certain conditions like glaucoma.

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4. Probiotics

best weight loss supplements

Probiotics are a form of beneficial gut bacteria that are effective for a good digestive system and gut balance. Strains like Bifidobacterium and Lactobacillus are proven to have decent weight loss effects, with studies showing that they can reduce body weight and BMI to a certain extent, with an average decrease in weight being under 1 kg [2].

You can consume the beneficial bacteria of probiotics in the form of supplements or naturally fermented foods like yogurt, kefir, and sauerkraut.

5. Berberine

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Berberine, also called “nature’s ozemptic”, is a plant-derived compound commonly found in the form of capsules and traditionally used in Chinese and Ayurvedic medicine. The National Center for Complementary and Integrative Health emphasizes the need for high-quality research to validate the claims related to berberine’s benefits [3]. It’s most well-known for improving insulin sensitivity, but research has shown that it can support weight loss too—A 2022 review of 41 trials has concluded that consuming this weight loss medication for 8 weeks has shown a dip in body weight and cholesterol levels.

However, it’s also worth noting that the participants were said to have a risk of bias along with other existing health conditions. One should also look out for gastrointestinal side effects like bloating and diarrhea.

6. Caffeine

best weight loss supplements

Caffeine is a popular addition in most weight loss journeys as it can be easily found in many everyday items like coffee and tea, alongside herbs and weight loss supplements. When combined with cardio exercises that help you lose weight naturally, coffee can add temporary boosts to your metabolism and fat-burning process.

Studies prove that caffeine can increase resting metabolic rate (RMR) by 3–11%, but the effects are most evident in lean individuals and can decline with age and long-term use [3]. Caffeine can also cause insomnia and heart palpitations in high doses, and it must be paired with other lifestyle changes for weight management to see visible results.

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7. Melatonin

best weight loss supplements

Best known for helping to regulate sleep cycles and other health goals, Melatonin also plays a lesser-known supportive role in weight loss journeys. Quality sleep is essential for maintaining a healthy weight and lifestyle, as poor sleep can lead to hormonal changes that affect appetite and cause weight gain.

Melatonin supplements as a weight loss pill indirectly help with efforts by regulating your circadian rhythms. A meta-analysis of 23 studies found that melatonin supplementation had led to a modest decrease in weight, with some studies showing losses of up to 0.76 kg [4].

8. GNC Total Lean Lean Shake

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Last but certainly not least, our final pick is in the form of a protein powder: GNC’s Total Lean® Lean Shake 25. Aside from offering a high dosage of protein, fiber, vitamins, and minerals, it has been designed to help with weight reduction. How it does this is by helping suppress your appetite and offering metabolic support.

It includes just 170 calories and 2g of sugar in a serving, making it perfect for low-carb and keto-friendly diets too. So, for the gym enthusiasts who are hoping to lose weight while achieving muscle mass, we recommend this one.

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Understanding Dietary Supplements

Before diving into the world of weight loss supplements, it’s good to know more about how they work and what they’re best suited for. They can be a good addition to other weight loss efforts in an individual’s journey, but they’re not a guaranteed solution, especially by themselves.

Prescription medications for weight loss are usually recommended for those with a body mass index above 30, or if you’re suffering from high blood pressure or diabetes, then a body mass index over 27. There are also some weight loss drugs like semaglutide and liraglutide that are approved for those aged 12 and older, but not for pregnant women. Whatever the medication may be, it’s always advisable to check in with a healthcare provider to ensure you suffer no possible side effects based on your medical history.

Non-prescription supplements are quite well-known and widely used, but the evidence supporting their effectiveness is not very strong. Clinical studies have proven that many supplements lead to minor weight loss, but no significant long-term results. But they can certainly help with managing appetite and boosting metabolism, which can contribute to losing weight. A fiber supplement can also be a valuable addition to a weight loss journey, as it can help reduce overall calorie intake and support healthy digestion.

Make sure to do your research on any pill, injection, or powder that you’re taking, because it has effects you’re unaware of. Taking high intakes of magnesium without knowing the consequences is an example, as it can possibly lead to cardiac arrest, and so the National Institute of Health recommends no more than 350-360 mg. By taking a holistic approach to weight loss, individuals can improve their overall health and increase their chances of long-term success.

Conclusion

In your weight loss journey, it’s always important to remember what a healthy weight is for you based on your body mass index. This is to ensure that you don’t fall prey to extreme strategies. Weight loss supplements can help with supporting your goals, but the end results also depend on various other factors like activity level, diet, initial body weight, sleep quality, etc. Consult a healthcare professional to ensure you’re making the right choices for your well-being and overall health. Managing excess weight is crucial for reducing the risk of chronic diseases and improving overall health. For more tips and resources to support weight management, check out the JustFit app!

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References  
Asbaghi, O., Ghanbari, N., Shekari, M., Reiner, Ž., Amirani, E., Hallajzadeh, J., Mirsafaei, L., & Asemi, Z. (2020). The effect of berberine supplementation on obesity parameters, inflammation and liver function enzymes: A systematic review and meta-analysis of randomized controlled trials. Clinical nutrition ESPEN38, 43–49. Available from: https://doi.org/10.1016/j.clnesp.2020.04.010 FDA. (n.d.). U.S. Food and Drug Administration. Available from: https://www.fda.gov/ Torres, B., Sánchez, M. C., Virto, L., Llama-Palacios, A., Ciudad, M. J., & Collado, L. (2024). Use of probiotics in preventing and treating excess weight and obesity. A systematic review. Obesity science & practice10(3), e759. Available from: https://doi.org/10.1002/osp4.759 Tsay, H. J., Liu, H. K., Kuo, Y. H., Chiu, C. S., Liang, C. C., Chung, C. W., Chen, C. C., Chen, Y. P., & Shiao, Y. J. (2021). EK100 and Antrodin C Improve Brain Amyloid Pathology in APP/PS1 Transgenic Mice by Promoting Microglial and Perivascular Clearance Pathways. International journal of molecular sciences22(19), 10413. Available from: https://doi.org/10.3390/ijms221910413 U.S. Department of Health and Human Services. (n.d.). Office of dietary supplements - dietary supplements for weight loss. NIH Office of Dietary Supplements. Available from: https://ods.od.nih.gov/factsheets/WeightLoss-HealthProfessional/
About authors
Meena is a dedicated copywriter and content creator with over three years of experience in crafting informative and impactful content. Her passion for health and personal interest in fitness shines through in her work, where she combines her writing expertise with a deep understanding of wellness. She aims to inspire and educate readers on their fitness journey.
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